Topics to be covered and reading schedule

Background Reading (not included in the courseware)

Rosenzweig, M. R., Leiman, A. L., & Breedlove, S. M. (1996). Biological psychology. Sunderland, MA: Sinauer Associates, 1996. (read chapter 17, 18)

On reserve in Health Sciences Library, WL 102 .R8195b 1996


Monday, Jan 4 -- Friday, Jan 15 (week 1 and 2)

Rosenzweig, M. R. (1998). Historical perspectives on the development of the biology of learning and memory. In J. Martinez & R. Kesner (Eds.), Neurobiology of learning and memory (pp. 1-53). San Diego, CA: Academic Press.


Monday, Jan 18 -- Friday, Jan 29 (week 3 and 4)

Multiple memory systems

Squire, L. R. (1993). The structure and organization of memory. Annual Review of Psychology, 44, 453-495.

Kesner, R. P., Bolland, B. L., & Dakis, M. (1993). Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex. Experimental Brain Research, 93, 462-470.

Monday, Feb 1 -- Friday, Feb 12 (week 5 and 6)


Eichenbaum, H., Schoenbaum, G., Young, B., & Bunsey, M. (1996). Functional organization of the hippocampal memory system. Proceedings of the National Academy of Science (U.S.A.), 93, 13500-13507.

Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., Van Paesschen, W., & Mishkin, M. (1997). Differential effects on early hippocampal pathology on episodic and semantic memory. Science, 277, 376-380.

Eichenbaum, H. (1997). How does the brain organize memories? Science, 277, 330-332.

Monday, Feb 15 -- Saturday, Feb 20 (mid-term recess)

Monday, Feb 22 -- Friday, Feb 26 (week 7)

Mid-term exam (one hour)


Kim, J. J., & Thompson, R. F. (1997). Cerebellar circuits and synaptic mechanisms involved in classical eyeblink conditioning. Trends in Neuroscience 20, 177-181.

Monday, Mar 1 -- Friday, Mar 12 (week 8 and 9)


Gilbert, C. D. (1993). Rapid dynamic changes in adult cerebral cortex. Current Opinion in Neurobiology, 3, 100-103.

Gilbert, C. D., & Wiesel, T. N. (1992). Receptive field dynamics in adult primary visual cortex. Nature, 356, 150-152.

Goldman-Rakic, P. S. (1996). Regional and cellular fractionation of working memory. Proceedings of the National Academy of Science (U. S. A), 93, 13473-13480.

Courtney, S. M., Ungerleider, L. G., Kell, K., & Haxby, J. V. (1997). Transient and sustained activity in a distributed neural system for human working memory. Nature, 386, 608-611.


Monday, Mar 15 -- Friday, Mar 26 (week 10 and 11)

Long-term potentiation

Martinez, J. L., & Derrick, B. E. (1996). Long-term potentiation and learning. Annual Review of Psychology, 47, 173-203.

Bliss, T. V. P., & Collingridge, G. L. (1993). A synaptic model of memory: Long-term potentiation. Nature, 361, 31-39.

Bannerman, D. M., Good, M. A., Butcher, S. P., Ramsay, M., & Morris, R. G. M. (1995). Distinct components of spatial learning revealed by prior training and NMDA receptor blockade. Nature, 378, 182-186.

Saucier, D., & Cain, D. P. (1995). Spatial learning without NMDA receptor-dependent long-term potentiation. Nature, 378, 186-189.

Eichenbaum, H. (1995). The LTP-memory connection. Nature, 378:131-132.

Monday, Mar 29 -- Monday, Apr 5 (week 12)

Aplysia model, Kandel's work

Bailey, C. I. L., Bartsch, D., & Kandel, E. R. (1996). Toward a molecular definition of long-term memory storage. Proceedings of the National Academy of Science (U. S. A), 93, 13445-13452.

Wednesday, Apr 7 -- Friday, Apr 9 (week 13)

Related researches in McMaster and some Canadian schools.

Review of the course.

Monday, Apr 12 - Wednesday, Apr 28

Final exam (to be scheduled)

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